Potassium bromide (KBr) is an anticonvulsant drug indicated for treatment of recurrent generalised tonic-clonic seizures in dogs with hepatic insufficiency and is frequently used as add-on therapy to phenobarbital.
Both phenobarbital and bromide are reasonable first-choice anticonvulsant drugs for dogs, but phenobarbital appears to be more effective and better tolerated during the first 6 months of treatment.
Side effects of KBr include reversible neurologic signs and are generally associated with adjunctive potassium bromide treatment or high serum bromide concentrations. Other side-effects include lethargy, weakness, decreased mentation, ataxia, paraparesis, polyphagia and gastrointestinal effects. Hematology usually reveals hyperkalemia.
Administration of potassium bromide with food may alleviate gastrointestinal irritation and it is recommended that monitoring be done for polyphagia, thyroid hormone abnormalities, and high serum bromide concentrations.
Recommended dose is 20 - 40 mg/kg once daily given orally as a starting dose.
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