Common causes of toxicosis relate to prescription errors in formulation of this drug but rare cases have been reported due to methyl bromide toxicity associated with fumigation processes in food processing.
The normal dose of KBr in dogs is 20 - 60 mg/kg.
Removal of KBr from the diet usually resolves clinical symptoms.
- Li J et al (2011) Subchronic toxicity and toxicokinetics of long-term intranasal administration of bencycloquidium bromide: a 91-day study in dogs. Regul Toxicol Pharmacol 59(2):343-352
- Piperisova I et al (2009) What is your diagnosis? Marked hyperchloremia in a dog. Vet Clin Pathol 38(3):411-414
- Wilson NH et al (2000) Methyl bromide 1-year dietary study in dogs. Food Chem Toxicol 38(1):115-124
- March PA et al (2002) Pharmacokinetics and toxicity of bromide following high-dose oral potassium bromide administration in healthy Beagles. J Vet Pharmacol Ther 25(6):425-432
- Gaskill CL & Cribb AE (2000) Pancreatitis associated with potassium bromide/ phenobarbital combination therapy in epileptic dogs. Can Vet J 41:555–558
- MacKay B & Mitchell G (1998) Spurious hyperchloraemia and negative anion gap in a dog with bromide toxicity. Aust Vet Pract 28:50–52
- Yohn SE et al (1992) Bromide toxicosis (bromism) in a dog treated with potassium bromide for refractory seizures. J Am Vet Med Assoc 201:468–470
- McConkey SE et al (2012) Compounding errors in 2 dogs receiving anticonvulsants. Can Vet J 53(4):391-394