Bromocriptine

From Dog
Parlodel01.jpg

Bromocryptine is an ergoline derived dopamine agonist which acts centrally in dogs.

This drug is sometimes used in the treatment of hyperadrenocorticism[1], pseudopregnancy[2] and to initiate oestrus induction[3] or lactation cessation.

Administration of bromocriptine shortens the anoestrus and is associated with a decrease in the plasma prolactin concentration, suggesting that the shortened anoestrus is the result of suppression of prolactin secretion[4].

This drug is also used in combination with misoprostol for pregnancy termination[5].

Recommended dose rate in dogs is 10 - 30 µg/kg given orally every 24 hours for 10 - 16 days.

References

  1. Braddock JA (2003) Medical treatment of hyperadrenocorticism in the dog. Aust Vet J 81(1-2):31-33
  2. Grünau B et al (1996) The treatment of pseudopregnancy in the bitch with prolactin inhibitors metergoline and bromocriptine. Tierarztl Prax 24(2):149-155
  3. Ajitkumar G et al (2010) Comparative efficacy of bromocriptine, cabergoline and thyroxine in inducing oestrus in bitches. Vet Res Commun 34(1):65-69
  4. Okkens AC & Kooistra HS (2006) Anoestrus in the dog: a fascinating story. Reprod Domest Anim 41(4):291-296
  5. Gobello C et al (2002) Use of prostaglandins and bromocriptine mesylate for pregnancy termination in bitches. J Am Vet Med Assoc 220(7):1017-1019