Busulfan

From Dog
Busulfan.jpg

Busulfan is a chemotherapy drug used for treatment of certain canine cancers. It has potent effects on bone marrow, resulting in suppression of bone marrow production of erythrocytes and leukocytes.

At doses of 10 - 30 mg/kg, busulfan produces a severe but in most cases reversible myelotoxicity[1].

This drug has been used for myeloblastic leukaemia, with limited responses[2].

It has also been used in combination with prednisolone to maintain remission in dogs with essential thrombocytopenia[3].

At high doses (10 mg/kg) it is myeloablative and is used prior to bone marrow transplantation in dogs with leucocyte adhesion deficiency[4].

Recommended dose rate is 3 - 4 mg/m2 or 0.1 mg/kg given orally every 24 hours.

References

  1. Abb J et al (1977) Effects of busulfan (BU) on hemopoiesis and immune reactivity in dogs. Biomedicine 26(6):403-408
  2. Keller P et al (1985) Acute myeloblastic leukaemia in a dog. J Comp Pathol 95(4):619-632
  3. Mizukoshi T et al (2006) Essential thrombocythemia in a dog. J Vet Med Sci 68(11):1203-1206
  4. Sokolic RA et al (2005) Nonmyeloablative conditioning with busulfan before matched littermate bone marrow transplantation results in reversal of the disease phenotype in canine leukocyte adhesion deficiency. Biol Blood Marrow Transplant 11(10):755-763