Cabergoline

From Dog

Cabergoline is a potent dopamine D2-receptor agonist, acting on on pituitary lactotroph (prolactin) cells.

It is used for pregnancy termination[1], estrus induction in anestrus bitches[2][3] or for treatment of pseudopregnancy.

Side-effects include milk loss post-partum[4].

Recommended dose for estrus induction is 10 - 20 IU/kg/day intramuscularly for 5 consecutive days, followed by an additional single injection of 25 IU/kg of human chorionic gonadotrophin on the fifth day.

References

  1. Cetin Y et al (2010) Intravaginal application of misoprostol improves pregnancy termination with cabergoline and alfaprostol in dogs. Berl Munch Tierarztl Wochenschr 123(5-6):236-242
  2. Ajitkumar G et al (2010) Comparative efficacy of bromocriptine, cabergoline and thyroxine in inducing oestrus in bitches. Vet Res Commun 34(1):65-69
  3. Nak D et al (2012) Comparison of the use of cabergoline and gonadotrophin to treat primary and secondary anoestrus in bitches. Aust Vet J 90(5):194-196
  4. Romagnoli S et al (2009) Effect of an injectable cabergoline formulation on serum prolactin (PRL) and milk secretion in early postpartum Beagle bitches. Reprod Domest Anim 44(2):148-151