Two variants of canine adenoviruses exist; type 1 and 2.
Although adenovirus type 2 is usually associated with upper respiratory disease, fatal canine adenoviral pneumonia has been reported in dogs, presenting with lethargy, dyspnea, nasal discharge, anorexia, vomiting, diarrhea and abdominal pain. Coinfection with Escherichia coli was involved.
There is no specific antiviral therapy for this disease, although broad-spectrum antimicrobial drugs are recommended in febrile cases.
All triannual core vaccines include attenuated live CAdV-2, which provides immunity to CAdV-1 and CAdV-2. CAdV-1 was initially used in a vaccine for dogs, but corneal edema was a common complication.
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