Capecitabine

From Dog
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Capecitabine is a chemotherapy prodrug that is chemically converted to 5-fluorouracil within tumors and inhibits DNA synthesis. It is not target specific and affects all rapidly dividing cells and acts as an immunosuppressive drug.

In dogs, this drug is primarily used in:

Side-effects have been noted, particularly development of chronic superficial keratitis[4].

Recommended dose rate is 25 mg/kg orally once daily for two weeks and ceased for one week, then repeated as a three-week cycle for 4 - 6 months.

References

  1. Milovancev M et al (2007) Use of capecitabine to prevent acute renal allograft rejection in dog erythrocyte antigen-mismatched mongrel dogs. Vet Surg 36(1):10-20
  2. Schmiedt C et al (2006) Use of capecitabine after renal allograft transplantation in dog erythrocyte antigen-matched dogs. Vet Surg 35(2):113-124
  3. Chang SC & Liao JW (2008) Mesojejunoileac liposarcoma with intrahepatic metastasis in a dog. J Vet Med Sci 70(6):637-640
  4. Zarfoss M et al (2007) Histopathologic evidence of capecitabine corneal toxicity in dogs. Vet Pathol 44(5):700-702