Carbenicillin

From Dog

Carbenicillin is a synthetic broad-spectrum β-Lactamase-Sensitive penicillin with extended spectrum against a number of bacteria.

This drug has relative efficacy against Streptococcus spp[1], Proteus spp, Klebsiella spp, Shigella spp and Enterobacter spp.

Because this drug is excreted in the urine[2], it may be suitable for dogs with cystitis.

Resistance has emerged with Staphylococcus spp[3] dermatitis and Pseudomonas aeruginosa[4].

Recommended dose rate in dogs is 15 - 30 mg/kg given orally or intravenously every 8 hours.

References

  1. Gerding PA et al (1988) Pathogenic bacteria and fungi associated with external ocular diseases in dogs: 131 cases (1981-1986). J Am Vet Med Assoc 193(2):242-244
  2. Hobbs DC (1972) Metabolism of indanyl carbenicillin by dogs, rats, and humans. Antimicrob Agents Chemother 2(4):272-275
  3. Hauschild T & Wójcik A (2007) Species distribution and properties of staphylococci from canine dermatitis. Res Vet Sci 82(1):1-6
  4. Lin D et al (2012) Characterization of antimicrobial resistance of Pseudomonas aeruginosa isolated from canine infections. J Appl Microbiol 113(1):16-23