Carcinosarcoma
From Dog
Microscopic appearance of a thyroid carcinosarcoma, showing spindle-shaped neoplastic cells lining and interspersed between irregular trabeculae of osteoid (arrow)[1]
Carcinosarcoma are a rare malignant canine tumor, usually affecting older dogs and characterized by tumors composed of both carcinoma and sarcoma with osseous elements[1].
These tumors consist of both malignant epithelial (follicular cells) and mesenchymal (usually osteogenic or cartilaginous or both) elements[2].
These tumors can be found in the thyroid gland, mammary gland (mammary carcinosarcoma)[3], lung[4], salivary gland[5], ceruminous gland[6], and eyelid[7].
These tumors are relatively aggressive and tend to metastasize and invade local tissues and surgical extirpation is not always successful, necessitating adjunctive chemotherapy and radiation therapy.
References
- ↑ 1.0 1.1 Grubor B & Haynes JS (2005) Thyroid carcinosarcoma in a dog. Vet Pathol 42(1):84-87
- ↑ Capen CC (2002) Tumors of the endocrine glands. In: Tumors in Domestic Animals, ed. Meuten DJ, 4th ed., pp. 638–684. Iowa State Press, Ames, IA
- ↑ Benjamin SA et al (1999) Classification and behavior of canine mammary epithelial neoplasms based on life-span observations in Beagles. Vet Pathol 36:423–436
- ↑ Salas G et al (2002) Lung carcinosarcoma in a dog: gross and microscopic examination. Vet J 163:331–334
- ↑ Perez-Martinez C et al (2000) Malignant fibrous histiocytoma (giant cell type) associated with a malignant mixed tumor in the salivary gland of a dog. Vet Pathol 37:350–353
- ↑ Moisan PG & Watson GL (1996) Ceruminous gland tumors in dogs and cats: a review of 124 cases. J Am Anim Hosp Assoc 32:449–453
- ↑ Hirai T et al (1997) Apocrine gland tumor of the eyelid in a dog. Vet Pathol 34:232–234
