Ceftiofur

From Dog

Ceftiofur is a cephalosporin-based bactericidal drug with activity against Gram-positive and Gram-negative bacteria.

This drug has good activity against Staphylococcus pseudintermedius[1] and Pasteurella multocida[2].

Resistance is noted against Salmonella spp, Pseudomonas aeruginosa[3] and Escherichia coli[4].

Recommended dose rate in dogs is 0.2 - 4.4 mg/kg, given subcutaneously[5].

References

  1. Onuma K et al (2012) Antimicrobial resistance of Staphylococcus pseudintermedius isolates from healthy dogs and dogs affected with pyoderma in Japan. Vet Dermatol 23(1):17-22
  2. Schwarz S et al (2007) Antimicrobial susceptibility of Pasteurella multocida and Bordetella bronchiseptica from dogs and cats as determined in the BfT-GermVet monitoring program 2004-2006. Berl Munch Tierarztl Wochenschr 120(9-10):423-430
  3. Rubin J et al (2008) Antimicrobial resistance and genetic characterization of fluoroquinolone resistance of Pseudomonas aeruginosa isolated from canine infections. Vet Microbiol 131(1-2):164-172
  4. Leonard EK et al (2012) Comparison of antimicrobial resistance patterns of Salmonella spp. and Escherichia coli recovered from pet dogs from volunteer households in Ontario (2005-06). J Antimicrob Chemother 67(1):174-181
  5. Brown SA et al (1995) Plasma and urine disposition and dose proportionality of ceftiofur and metabolites in dogs after subcutaneous administration of ceftiofur sodium. J Vet Pharmacol Ther 18(5):363-369