Chlorothiazide

From Dog

Chlorothiazide is a diuretic similar in action to hydrochlorothiazide as an efflux transporter, but has low oral bioavailability[1].

It is used for treatment of calcium oxalate uroliths[2] and in low doses, for management of nephrogenic diabetes insipidus[3].

Recommended dose rate in dogs is 10 - 40 mg/kg given orally every 12 - 24 hours[4].

References

  1. Beéry E et al (2012) ABCG2 modulates chlorothiazide permeability--in vitro-characterization of its interactions. Drug Metab Pharmacokinet 27(3):349-353
  2. Lulich JP et al (2001) Effects of hydrochlorothiazide and diet in dogs with calcium oxalate urolithiasis. J Am Vet Med Assoc 218(10):1583-1586
  3. Takemura N (1998) Successful long-term treatment of congenital nephrogenic diabetes insipidus in a dog. J Small Anim Pract 39(12):592-594
  4. Khaled KA et al (2001) In vivo evaluation of hydrochlorothiazide liquisolid tablets in beagle dogs. Int J Pharm 222(1):1-6