Chondroitin

From Dog

Chondroitin sulfate is a neutriceutical used as a supplement for treating canine arthritis[1].

Chondroitin is a peptidoglycan normally found in most connective tissues, especially synovial joints. Chondroitin sulfate is a heterogenous group of compounds that have different molecular masses (15,000-25,000 kDa) and electric change densities[2] and are an essential component of the connective tissue extracellular matrix, including hyaline cartilage and chondroitin provide elasticity and other functions[3].

Age-related loss of production is associated with increased wear and tear radiographic changes associated with arthritis. Oral supplementation has shown to improve joint cartilage repair, although this appears to not be a dose-related response[4].

This drug is not hyperglycemia inducing and is relatively safe to use in dogs with diabetes mellitus[5].

Recommended dose rate in dogs is 5 - 10 mg/kg given orally once daily.

References

  1. Gupta RC et al (2012) Comparative therapeutic efficacy and safety of type-II collagen (UC-II), glucosamine and chondroitin in arthritic dogs: pain evaluation by ground force plate. J Anim Physiol Anim Nutr (Berl) 96(5):770-777
  2. Kelly GS (1998) The role of glucosamine sulfate and chondroitin sulfates in the treatment of degenerative joint disease. Altern Med Rev 3:27–39
  3. Nganvongpanit K et al (2008) Evaluation of serum chondroitin sulfate and hyaluronan: biomarkers for osteoarthritis in canine hip dysplasia. J Vet Sci 9(3):317-325
  4. McKenzie BA (2010) What is the evidence? There is only very weak clinical trial evidence to support the use of glucosamine and chondroitin supplements for osteoarthritis in dogs. J Am Vet Med Assoc 237(12):1382-1383
  5. Lenox CE & Lunn KF (2010) Effects of glucosamine-chondroitin sulfate supplementation on serum fructosamine concentration in healthy dogs. J Am Vet Med Assoc 236(2):183-186