Cimetidine

From Dog
Cimetidine.jpg

Cimetidine is an histamine H2-receptor antagonist that inhibits the production of stomach acid as well as having antiemetic properties.

Cimetidine is indicated for use in NSAID-induced oesophagitis[1], oesophageal strictures[2], gastritis associated with Helicobacter spp infection and as an antiemetic[3] and immunomodulator[4].

It does however appear to be pharmacologically less effective than omeprazole in reducing gastric acid production.

Recommended dose for use in dogs is 5 - 15 mg/kg given orally every 8 - 12 hours.

It appears to be safe when used long term and when in combination with other drugs.

References

  1. Song HJ et al (2009) Eupatilin with heme oxygenase-1-inducing ability protects cultured feline esophageal epithelial cells from cell damage caused by indomethacin. Biol Pharm Bull 32(4):589-596
  2. Leib MS et al (2001) Endoscopic balloon dilation of benign esophageal strictures in dogs and cats. J Vet Intern Med 15(6):547-552
  3. Japundzić-Zigon N et al (1997) Clonidine-induced emesis: a multitransmitter pathway concept. Pharmacol Res 35(4):287-297
  4. Akoev GN et al (1996) Mast cell mediators excite the afferents of cat small intestine. Neuroscience 71(4):1163-1166