Cisplatin

From Dog

Cisplatin is a chemotherapy drug used in canine medicine for treatment of osteosarcoma, lymphoma, mesothelioma and squamous cell carcinoma.

Cisplatin is a platinum-containing drug similar to carboplatin which cross-links DNA, resulting in cell apoptosis.

It frequently is used to treat non-resectable or widespread carcinomas and may be administered intravenously, intraperitoneally or intra-lesionally.

The most-common side-effect is vomiting within six hours of treatment. This may be managed by pre-treatment with antiemetics such as butorphanol, dexamethasone and metoclopramide. The degree of GI toxicity may be dose-related.

Recommended dose in dogs is 60 mg/m2 (given as a 1 mg/mL in 0.9% sodium chloride) intravenously at 3-week intervals.