Clopidogrel

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Clopidogrel is an oral thienopyridine class antiplatelet agent used in canine medicine for treatment of immune-mediated hemolytic anemia[1] and heartworm disease.

Although clopidogrel can be used safely in conjunction with aspirin[2], significant reactions occur with concurrent use of cyclosporine and is not recommended in this dual-drug therapy[3].

Administration at doses ranging from 0.5 - 4.0 mg/kg every 24 hours results in significant antiplatelet effects[4].

References

  1. Mellett AM et al (2011) A prospective study of clopidogrel therapy in dogs with primary immune-mediated hemolytic anemia. J Vet Intern Med 25(1):71-75
  2. Zurbrügg HR et al (2001) Prevention of venous graft sclerosis with clopidogrel and aspirin combined with a mesh tubing in a dog model of arteriovenous bypass grafting. Eur J Vasc Endovasc Surg 22(4):337-341
  3. Lee JH et al (2012) Pharmacokinetic interactions of clopidogrel with quercetin, telmisartan, and cyclosporine A in rats and dogs. Arch Pharm Res 35(10):1831-1837
  4. Brainard BM et al (2010) Pharmacodynamic and pharmacokinetic evaluation of clopidogrel and the carboxylic acid metabolite SR 26334 in healthy dogs. Am J Vet Res 71(7):822-830