Clotrimazole

From Dog

Clotrimazole is a topical antifungal agent that alters the permeability of the fungal cell wall and inhibits the activity of intracellular enzymes by inhibiting the biosynthesis of ergosterol and other sterols.

It is commonly formulated as a 1 per cent solution flush[1] or 1% clotrimazole gel formulated with hydroxypropyl cellulose, poloxamer or carboxymethylcellulose sodium bases[2].

In canine medicine, clotrimazole is used for treatment of infections with ringworm, Malassezia spp[3] or mycotic rhinitis[4][5].

It has also been used for treatment of urinary infections with Candida spp[6] via intermittent bladder infusions.

References

  1. Sissener TR et al (2006) Combined clotrimazole irrigation and depot therapy for canine nasal aspergillosis. J Small Anim Pract 47(6):312-315
  2. Mathews KG et al (2009) Assessment of clotrimazole gels for in vitro stability and in vivo retention in the frontal sinus of dogs. Am J Vet Res 70(5):640-647
  3. Bensignor E & Grandemange E (2006) Comparison of an antifungal agent with a mixture of antifungal, antibiotic and corticosteroid agents for the treatment of Malassezia species otitis in dogs. Vet Rec 158(6):193-195
  4. Sharman M et al (2012) Clotrimazole and enilconazole distribution within the frontal sinuses and nasal cavity of nine dogs with sinonasal aspergillosis. J Small Anim Pract 53(3):161-167
  5. Bruskiewicz K et al (2011) Pseudallescheria boydii species complex fungal rhinitis and sinusitis in a dog. J Am Anim Hosp Assoc 47(5):365-369
  6. Forward ZA et al (2002) Use of intermittent bladder infusion with clotrimazole for treatment of candiduria in a dog. J Am Vet Med Assoc 220(10):1496-1498