Cloxacillin is a synthetic penicillin derivative, effective against a range of Gram-positive and some Gram-negative bacteria.
This drug has a weaker antibacterial activity than benzylpenicillin, and is devoid of serious toxicity except for allergic reactions.
Recommended dose rate is 20 - 40 mg/kg given orally, intramuscularly or intravenously every 4 - 8 hours.
- Lawrence SL et al (2005) Cloxacillin versus vancomycin for presumed late-onset sepsis in the Neonatal Intensive Care Unit and the impact upon outcome of coagulase negative staphylococcal bacteremia: a retrospective cohort study. BMC Pediatr 5:49
- Hoekstra KA & Paulton RJ (2002) Clinical prevalence and antimicrobial susceptibility of Staphylococcus aureus and Staph. intermedius in dogs. J Appl Microbiol 93(3):406-413
- Lobetti RG et al (2002) Bacterial colonization of intravenous catheters in young dogs suspected to have parvoviral enteritis. J Am Vet Med Assoc 220(9):1321-1324