Despite having no detectable antigenic C3, C3-deficient dog serum has approximately 10% of normal serum C3 hemolytic activity.
This condition in dogs appear to mirror genetically the same condition observed in humans.
Dogs that are homozygous for the trait have no detectable C3, while heterozygous dogs have serum C3 concentrations approximately 30 to 50% of normal. Only homozygous dogs are clinically affected, but heterozygotes (carriers) can pass on the trait to their offspring.
Affected animals have markedly reduced levels of serum opsonic and chemotactic activities, leading to increased susceptibility to bacterial infections. There appears to be no correlation between this condition and a predisposition to demodicosis.
Although there is no specific treatment for this condition, antimicrobial therapy is remedial when acute bacterial infections are evident clinically.
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