Creatine phosphate is a high energy compound used by muscle and brain tissues, and during phosphorylation through the action of creatinine kinase, it is converted to creatinine, which is a metabolic end product that is excreted primarily through the kidney.
Serum levels of creatinine are a good indicator of renal health and elevated levels (hypercreatininemia) above the normal range of 0.5 - 1.6 mg/dL reflect underlying renal pathology.
Diseases associated with elevated creatinine include:
- Low-protein diets
- Starvation - have associated elevation in creatinine kinase
- Acute renal injury
- Chronic renal disease
- Congestive heart failure - resulting in poor renal perfusion
- Nephrotic syndrome
- Malignant hyperthermia
- Leptospira spp
- Renal amyloidosis
- Juvenile hypercreatininemia in Beagles
In patients with elevated serum creatinine levels, an estimate of glomerular filtration rate is conducted by evaluating urine protein:creatinine ratio or urine corticoid:creatinine ratio.
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