Cutaneous mucinosis (cutaneous hyaluronosis) is a skin disease of dogs characterized by the accumulation of excessive amounts of dermal collagen, elastic fibres, vessels and mucopolysaccharide hyaluronan (ground substance).
In the Shar Pei, a preponderance of epithelial mast cells and circulating levels of hyaluronic acid are involved in this hereditary condition, which may predispose to future development of mast cell tumors in this breed.
In most dogs, cutaneous mucinosis presents as a distinctive area of alopecia and wrinkled and thickened skin.
A diagnosis is usually based on visual examination of skin and biopsies for histological examination.
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