Cyclizine

From Dog

Cyclizine is an antiemetic drug used for control of vomiting in dogs[1].

This drug works as an H2 receptor antagonist and is biotransformed by the liver and excreted as a metabolite in the urine[2].

Greyhound drug testing routinely screens this chemical in the urine as well as other illicit compounds such as stanozolol, caffeine, procaine and quinine[3][4].

Recommended dose rate in dogs is 4 mg/kg given intramuscularly every 8 hours as required.

References

  1. Radkevich LA (1977) Model of motion sickness in dogs for assessing the effectiveness of pharmacological substances. Kosm Biol Aviakosm Med 11(6):50-53
  2. Dumasia MC (2002) Biotransformation of cyclizine in greyhounds. 2: N(1)-dealkylation and identification of some neutral and phenolic metabolites in canine urine by gas chromatography-mass spectrometry. Xenobiotica 32(9):809-821
  3. Dumasia MC et al (2002) Biotransformation of cyclizine in greyhounds. 1: Identification and analysis of cyclizine and some basic metabolites in canine urine by gas chromatography-mass spectrometry. Xenobiotica 32(9):795-807
  4. Moore CM (1990) Solid-phase cation exchange extraction of basic drugs from the urine of racing greyhounds. J Forensic Sci Soc '30(3):123-9