Dapsone

From Dog

Dapsone (diamino-diphenyl sulfone) is an antibacterial sulphur drug which inhibits bacterial synthesis of dihydrofolic acid.

It also stabilized granulocyte membranes, resisting endotoxemia associated with bacterial infections[1] or spider bites.

Dapsone has been used in combination with rifampicin, moxifloxacin and clofazimine as part of a multidrug therapy for canine mycobacterial granulomas[2].

Dapsone has also been used in nasal rhinosporidiosis[3] and in combination with cyclophosphamide and sulfasalazine for treatment of canine pemphigus foliaceus[4].

Recommended dose rate in dogs is 1.1 mg/kg given orally every 12 hours for 4 - 6 weeks.

References

  1. Mayers I et al (1994) Pulmonary vascular effects of endotoxin in canine lobes pretreated with dapsone. Circ Shock 42(1):44-52
  2. Malik R et al (2013) Ulcerated and nonulcerated nontuberculous cutaneous mycobacterial granulomas in cats and dogs. Vet Dermatol 24(1):146-153
  3. Allison N et al (1986) Nasal rhinosporidiosis in two dogs. J Am Vet Med Assoc 188(8):869-871
  4. Rosenkrantz WS et al (2004) Pemphigus: current therapy. Vet Dermatol 15(2):90-98