Deferoxamine

From Dog

Deferoxamine mesylate is an iron-chelating and antioxidant agent[1] used in human medicine for treatment of thalassemia and oxidative damage associated with severe burns[2].

In canine medicine, it is commonly used for treatment of iron toxicity associated with ingestion of moisture/oxygen absorbers (package inserts)[3] and commercial snail and slug bait containing iron EDTA[4].

Chelation therapy with desferrioxamine mesylate causes few adverse effects when given at recommended doses.

Recommended dose rate in dogs is 10 mg/kg given parenterally every 2 hours for 2 doses then every 8 hours for 24 hours.

References

  1. Davis S et al (1997) Parallel antioxidant and antiexcitotoxic therapy improves outcome after incomplete global cerebral ischemia in dogs. Stroke 28(1):198-204
  2. Groebler LK et al (2011) Comparing the potential renal protective activity of desferrioxamine B and the novel chelator desferrioxamine B-N-(3-hydroxyadamant-1-yl)carboxamide in a cell model of myoglobinuria. Biochem J 435(3):669-677
  3. Brutlag AG et al (2012) Iron intoxication in a dog consequent to the ingestion of oxygen absorber sachets in pet treat packaging. J Med Toxicol 8(1):76-79
  4. Haldane SL & Davis RM (2009) Acute toxicity in five dogs after ingestion of a commercial snail and slug bait containing iron EDTA. Aust Vet J 87(7):284-286