Diazepam

From Dog

Diazepam is an anxiolytic benzodiazepine drug used as a sedative, anxiolytic, pre-anaesthetic and seizure[1] medication.

A similar drug, clorazepate, is metabolized by the dog to diazepam and has virtually identical properties[2].

In dogs, it is commonly used to combat separation anxiety[3], storm fears, during transport and as a general anesthetic used in combination with ketamine[4] or fentanyl[5].

The effects of diazepam can be counteracted by the benzodiazepine antagonist flumazenil[6].

Recommended dose rate of diazepam in dogs is 0.5 - 1.0 mg/kg one to two times daily given orally.

References

  1. Raith K et al (2010) Continuous electroencephalographic monitoring of status epilepticus in dogs and cats: 10 patients (2004-2005). J Vet Emerg Crit Care (San Antonio) 20(4):446-455
  2. Scherkl R et al (1989) Clorazepate in dogs: tolerance to the anticonvulsant effect and signs of physical dependence. Epilepsy Res 3(2):144-150
  3. Herron ME et al (2008) Retrospective evaluation of the effects of diazepam in dogs with anxiety-related behavior problems. J Am Vet Med Assoc 233(9):1420-1424
  4. Kovalcuka L et al (2013) The effects of ketamine hydrochloride and diazepam on the intraocular pressure and pupil diameter of the dog's eye. Vet Ophthalmol 16(1):29-34
  5. Psatha E et al (2011) Clinical efficacy and cardiorespiratory effects of alfaxalone, or diazepam/fentanyl for induction of anaesthesia in dogs that are a poor anaesthetic risk. Vet Anaesth Analg 38(1):24-36
  6. Heniff MS et al (1997) Comparison of routes of flumazenil administration to reverse midazolam-induced respiratory depression in a canine model. Acad Emerg Med 4(12):1115-1118