Dobutamine

From Dog

Dobutamine is a synthetic sympathomimetic drug used in the treatment of hypotension associated with congestive heart failure, sepsis associated with peritonitis and other life-threatening cases of cardiogenic or hemorrhagic shock[1].

Its primary mechanism is direct stimulation of β1-receptors of the sympathetic nervous system, resulting in increased heart rate and cardiac contractility[2].

This drug is also used as a diagnostic tool with dysautonomia[3].

Recommended dose rates in dogs is 2 - 20 µg/kg/min given as an intravenous constant rate infusion.

References

  1. Du W et al (2012) Dobutamine stress echocardiography assessment of myocardial contusion due to blunt impact in dogs. Cell Biochem Biophys 62(1):169-175
  2. Hori Y et al (2009) The relationship between invasive hemodynamic measurements and tissue Doppler-derived myocardial velocity and acceleration during isovolumic relaxation in healthy dogs. J Vet Med Sci 71(11):1419-1425
  3. Harkin KR et al (2009) Echocardiographic evaluation of dogs with dysautonomia. J Am Vet Med Assoc 235(12):1431-1436