Ondansetron

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Ondansetron.jpg

Ondansetron, granisetron and dolasetron are antiemetics with 5-HT3 receptor antagonist activity, both in the central nervous system and gastrointestinal tract and have an antiemetic effect equivalent to maropitant[1].

These drugs appear effective for use with refractory vomiting associated with chemotherapy in dogs and pancreatitis.

Significant side effects are rarely noted, except in some dogs with multi-drug sensitivity such as the Collie. In humans, headache and diarrhoea are reported most commonly[2].

Dolasetron has also been associated with prolongation of the QT interval in humans, with hypokalemia as a risk factor. This has also been reported with use of cisapride in humans.

The empirical dosage for use of dolasetron is 0.6 - 1.0 mg/kg IV or PO once daily; ondasetron dosage is 0.5 mg/kg IV or PO twice daily.

References

  1. Sedlacek HS et al (2008) Comparative efficacy of maropitant and selected drugs in preventing emesis induced by centrally or peripherally acting emetogens in dogs. J Vet Pharmacol Ther 31(6):533-537
  2. Goodin, S & Cunningham, R (2002) 5-HT(3)-receptro antagonists for the treatment of nausea and vomiting; a reappraisal of their side-effect profile. Oncologist 7:424-436