Doxapram

From Dog

Doxapram is a respiratory stimulant which acts on the carotid body sinus, resulting in secondary respiratory centre stimulation.

Although commonly used in canine neonates as a respiratory stimulant, is it also used in accidental barbiturate overdose during induction of general anesthesia or to assist recovery rate[1].

Doxapram is also used to assist a diagnosis of laryngeal paralysis via endoscopy[2].

Recommended dose rate in dogs is 1 - 5 mg/kg given intravenously to effect.

References

  1. Nicholson A & Watson A (2001) Survey on small animal anaesthesia. Aust Vet J 79(9):613-619
  2. Tobias KM et al (2004) Effects of doxapram HCl on laryngeal function of normal dogs and dogs with naturally occurring laryngeal paralysis. Vet Anaesth Analg 31(4):258-263