Pegylated liposomal doxorubicin (PL-DOX) is a chemotherapy drug as a formulation of doxorubicin in poly(ethylene glycol)-coated (stealth) liposomes with a prolonged circulation time and unique toxicity profile.
The polyethylene glycol coating results in preferential concentration of Doxil in the region of injection, with reduced toxicity and enhanced local antitumor activity. Although the single maximum tolerated dose of Doxil is actually lower than that of conventionally administered doxorubicin, the cumulative dose may be substantially greater than that of free doxorubicin.
It has been used as a monotherpay in treatment of hemangiosarcoma in dogs. Variable responses have been reported, when compared with doxorubicin and this drug appears to not prevent intra-abdominal metastases with hemangiosarcoma.
Side-effects have been reported, primarily dose-limiting mucocutaneous toxicities, mild myelosuppression, alopecia, anaphylaxis or desquamating dermatitis similar to palmar-plantar erythrodysesthesia. These effects can be mitigated by use of pyridoxine at 25 - 50 mg given orally every 8 hours.
Recommended dose rate is 10 - 12.5 mg/m2; equating to 0.5 mg/kg every l, 2, or 4 weeks, 1.0 mg/kg every 2 weeks, or 1.5 mg/kg every 4 weeks for 12 weeks.
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