Edrophonium

From Dog

Edrophonium (Tensilon) is a short-acting acetylcholinesterase inhibitor which acts on neuromuscular junctions in muscle.

In dogs, this drug is primarily used to assist a clinical diagnosis of myasthenia gravis and dogs which respond to this drug, showing improved muscle performance, suggest an underlying MG predisposition.

Long-acting anticholinesterase drugs are then used for maintenance of MG-affected dogs, e.g., pyridostigmine (1-3 mg/kg PO, bid-tid) or neostigmine (0.04 mg/kg, SC, qid)[1].

Edrophonium also counteracts the effects of vecuronium-induced neuromuscular blockade during general anesthesia[2].

Recommended dose rate in dogs is 0.5 - 2.5 mg/dog given intravenously.

References

  1. Foy DS et al (2011) Cholinergic crisis after neostigmine administration in a dog with acquired focal myasthenia gravis. J Vet Emerg Crit Care (San Antonio) 21(5):547-551
  2. Clutton RE (1994) Edrophonium for the antagonism of neuromuscular blockade in dogs. Vet Rec 134(26):674-678