Endarteritis is defined as intimal proliferation, inflammation and secondary fibrous changes of the endothelial lining of arteries.
Chronic changes lead to weakening of supportive fibrous tissues, with a predisposition to eventual rupture of the vessel.
in dogs, this is often synonymous with heartworm disease where mechanical irritation of worms against the arterial lining results in thickening and narrowing of the blood vessels.
Endarteritis becomes more prevalent in cases where adult worms die and result in mechanical occlusion and secondary thromboembolism.
Endarteritis is also observed with:
- Steroid responsive meningitis-arteritis
- Patent ductus arteriosus, mitral valve endocardiosis
- Chronic sepsis
- Giles RC & Hildebrandt PK (1973) Ruptured pulmonary artery in a dog with dirofilariasis. J Am Vet Med Assoc 163(3):236-238
- Maiolini A et al (2013) Interleukin-6, vascular endothelial growth factor and transforming growth factor beta 1 in canine steroid responsive meningitis-arteritis. BMC Vet Res 9(1):23
- Peterson PB et al (2003) Septic pericarditis, aortic endarteritis, and osteomyelitis in a dog. J Am Anim Hosp Assoc 39(6):528-532