Enoxaparin

From Dog

Enoxaparin binds to and accelerates the activity of antithrombin III. By activating antithrombin III, enoxaparin preferentially potentiates the inhibition of coagulation factors Xa and IIa[1].

This drug is used in dogs to prevent thromboembolism associated with DIC and heartworm disease.

Recommended dose in dogs is 100 U/kg given subcutaneously as a single injection[2].

References

  1. Stassen JM et al (1993) Comparative effects of enoxaparin and heparin on arterial and venous clot lysis with alteplase in dogs. Thromb Haemost 69(5):454-459
  2. Yoon WK et al (2011) Catheter-guided percutaneous heartworm removal using a nitinol basket in dogs with caval syndrome. J Vet Sci 12(2):199-201