Factor II deficiency
This disease is characterized by prothrombin defects caused by both hypo- and dys-prothrominemia.
Clinical symptoms are primarily mild to moderately severe bleeding, epistaxis and umbilical bleeding in newborn puppies.
No treatment is usually required, although in severely affected pups, intravenous frozen plasma or cryoprecipitate may be required.
- Hill BL et al (1982) Prothrombin deficiency in a cocker spaniel. J Am Vet Med Assoc 181(3):262-263
- Fouts, PJ et al (1940) Factor II deficiency in dogs. J Nutrition
- Bonk RJ et al (1986) Automated synthetic substrate assays for coagulopathies of dogs. Lab Anim Sci '36(5):517-21