Factor II deficiency

From Dog

Factor II deficiency is a rare autosomal-recessive genetic form of hemophilia,

This disease is characterized by prothrombin defects caused by both hypo- and dys-prothrominemia.

Factor II deficiency has been reported in the Boxer. A prothrombin deficiency has also been reported in the English Cocker Spaniel[1] as well as dogs fed casein rice feeds high in vitamin B6[2].

Clinical symptoms are primarily mild to moderately severe bleeding, epistaxis and umbilical bleeding in newborn puppies.

In adult dogs, subpepidermal hematomas and dermatitis may also occur but episodes of bleeding tend to become less frequent.

Blood coagulation screening tests are usually normal but factor II levels may be elevated in dogs with factor VII deficiency[3].

No treatment is usually required, although in severely affected pups, intravenous frozen plasma or cryoprecipitate may be required.


  1. Hill BL et al (1982) Prothrombin deficiency in a cocker spaniel. J Am Vet Med Assoc 181(3):262-263
  2. Fouts, PJ et al (1940) Factor II deficiency in dogs. J Nutrition
  3. Bonk RJ et al (1986) Automated synthetic substrate assays for coagulopathies of dogs. Lab Anim Sci '36(5):517-21