Famotidine

From Dog
Famotidine.jpg

Famotidine is a H2 receptor antagonist for use in control of vomiting in dogs.

This antiemetic drug reduces gastric acid secretion and is more potent than ranitidine, and has a similar duration of action[1].

It may be useful in severe or persistent vomiting, where secondary reflux and oesophagitis are present.

It is also useful in gastrinoma which results in increased gastrin concentrations. Other uses include mast cell tumor, where overproduction of histamine is generated by tumour cells.

The recommended dose rate in dogs is 0.5 - 1.0 mg/kg once or twice daily.

References

  1. Coruzzi, G et al (1986) Inhibitory effect of famotidine on cat gastric secretion. Agents Actions 19:188-193