Fampridine

From Dog

Fampridine (4-Aminopyridine) is an isomeric derivative of pyridine which blocks potassium channels, prolonging action potentials and thereby increasing neurotransmitter release at the neuromuscular junction.

It is a lipid-soluble drug which readily crosses the blood-brain barrier.

It is used primarily for neurological signs associated with CNS disease due to its ability to restore conduction to demyelinated axons and improve neurological function[1].

Use of fampridine has shown to improve clinical responses in cases of vestibular disease[2], various motor neurone diseases[3] and tetrodotoxin poisoning[1].

Side-effects and toxicosis have been reported, with symptoms of seizures and atrial fibrillation.

Recommended dose rate is 0.1 - 0.5 mg/kg given once daily.

References

  1. 1.0 1.1 Olby NJ et al (2009) Pharmacokinetics of 4-aminopyridine derivatives in dogs. J Vet Pharmacol Ther 32(5):485-491
  2. Hopkins AL & Clarke J (2010) Episodic cerebellar dysfunction in a bichon frise: a canine case of episodic ataxia? J Small Anim Pract 51(8):444-446
  3. Pinter MJ et al (1997) Effects of 4-aminopyridine on muscle and motor unit force in canine motor neuron disease. J Neurosci 17(11):4500-4507