Fenbendazole

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Fenbendazole (Panacur) is a broad spectrum benzimidazole anthelmintic used against nematodes, trematodes and protozoa.

It has comparative pharmacokinetics to other benzimidazoles such as albendazole and oxfendazole[1].

It has proven efficacy against Toxocara canis[2], Angiostrongylus vasorum[3], Oslerus osleri[4], Strongyloides stercoralis[5], Taenia spp[6], Capillaria plica[7], Mesocestoides spp[8], Crenosoma vulpis[9]Eucoleus boehmi[10] and Giardia spp.

When used in combination with praziquantel, fenbendazole also has efficacy against Heterobilharzia americana[11].

Few side-effects occur at recommended doses, but rare cases of bone marrow hypoplasia[12] and drug-induced, thrombo-ischaemic necrosis of the pinnae have been reported[13].

Recommended dose in dogs is 50 - 100 mg/kg given once daily for 3 days (nematodes) and 10 - 14 days (flukes)

References

  1. Gokbulut C et al (2007) Comparative plasma disposition of fenbendazole, oxfendazole and albendazole in dogs. Vet Parasitol 148(3-4):279-287
  2. Dryden MW & Ridley RK (1999) Efficacy of fenbendazole granules and pyrantel pamoate suspension against Toxocara canis in greyhounds housed in contaminated runs. Vet Parasitol 82(4):311-315
  3. Gallagher B et al (2012)
  4. Bourdoiseau G et al (1994) Oslerosis of the dog: diagnostic and therapeutic status. Parasite 1(4):369-378
  5. Itoh N et al (2009) Fenbendazole treatment of dogs with naturally acquired Strongyloides stercoralis infection. Vet Rec 164(18):559-560
  6. Miró G et al (2007) Survey of intestinal parasites in stray dogs in the Madrid area and comparison of the efficacy of three anthelmintics in naturally infected dogs. Parasitol Res 100(2):317-320
  7. van Veen L (2002) Bladder infection with Capillaria plica in a male dog. Tijdschr Diergeneeskd 127(12):393-394
  8. Boyce W et al (2011) Survival analysis of dogs diagnosed with canine peritoneal larval cestodiasis (Mesocestoides spp.). Vet Parasitol 180(3-4):256-261
  9. Bihr T & Conboy GA (1999) Lungworm (Crenosoma vulpis) infection in dogs on Prince Edward Island. Can Vet J 40(8):555-559
  10. Clark AC et al (2013) Intracranial migration of Eucoleus (Capillaria) boehmi in a dog. J Small Anim Pract 54(2):99-103
  11. Ruth J (2010) Heterobilharzia americana Infection and Glomerulonephritis in a Dog. J Am Anim Hosp Assoc 46(3):203-208
  12. Gary AT et al (2004) Bone marrow hypoplasia associated with fenbendazole administration in a dog. J Am Anim Hosp Assoc 40(3):224-229
  13. Nuttall TJ et al (2005) Thrombo-ischaemic pinnal necrosis associated with fenbendazole treatment in a dog. J Small Anim Pract 46(5):243-246