From Dog

Fexofenadine is an oral H1 receptor antagonist antihistamine drug with little CNS depressant effects[1] due to its lack of blood-brain barrier penetration[2].

This drug is mainly eliminated from the liver into bile in unchanged form[3].

Fexofenadine is primarily used in dogs with rhinitis-associated allergies, but has been shown to limit metastases associated with mast cell tumors[4].

It appears to be ineffective at controlling pruritus assocated with canine atopy[5].

Recommended dose rate in dogs is 0.1 mg/kg given orally once or twice daily[6].


  1. Markham A & Wagstaff AJ (1998) Fexofenadine. Drugs 55(2):269-274
  2. Obradovic T et al (2007) Assessment of the first and second generation antihistamines brain penetration and role of P-glycoprotein. Pharm Res 24(2):318-327
  3. Matsushima S et al (2008) Involvement of multiple efflux transporters in hepatic disposition of fexofenadine. Mol Pharmacol 73(5):1474-1483
  4. Hadzijusufovic E et al (2010) H1-receptor antagonists terfenadine and loratadine inhibit spontaneous growth of neoplastic mast cells. Exp Hematol 38(10):896-907
  5. Olivry T & Bizikova P (2013) A systematic review of randomized controlled trials for prevention or treatment of atopic dermatitis in dogs: 2008-2011 update. Vet Dermatol 24(1):97-117
  6. Kitamura Y et al (2008) Modest effect of impaired P-glycoprotein on the plasma concentrations of fexofenadine, quinidine, and loperamide following oral administration in collies. Drug Metab Dispos 36(5):807-810