Fluorouracil is an antineoplastic antimetabolite drug used for chemotherapy in dogs associated with squamous cell carcinoma.
Fluorouracil is a pyrimidine analog which inhibits thymidylate synthase, an important cellular protein.
The recommended dose in dogs is 12 mg/kg are given intravenously once daily for 4 successive days. The daily dose should not exceed 800 mg.
Side effects include gastrointestinal ulceration and bleeding, generalized allergic reactions, nystagmus and ataxia.