Fluorouracil

From Dog

Fluorouracil is an antineoplastic antimetabolite drug used for chemotherapy in dogs associated with squamous cell carcinoma.

Fluorouracil is a pyrimidine analog which inhibits thymidylate synthase, an important cellular protein.

A prodrug of 5-fluorouracil, capecitabine, shows promise for neoplasms such as liposarcoma.

The recommended dose in dogs is 12 mg/kg are given intravenously once daily for 4 successive days. The daily dose should not exceed 800 mg.

Side effects include gastrointestinal ulceration and bleeding, generalized allergic reactions, nystagmus and ataxia.