Fotemustine

From Dog

Fotemustine is a chloroethylating nitrosourea alkylating agents similar to lomustine and carmustine[1].

This drug is a cytostatic chemotherapy agent of the nitrosourea family with an alkylating and carbamoylating effect with a wide spectrum of experimental antitumoral activity. Fotemustine it is rapdily absorbed by intravenous injection and crosses the blood-brain barrier[2].

It has been used in humans for metastatic melanoma, but in dogs is primarily used as a rescue agent in lymphoma.

Complete azospermia was observed at doses of > 3.5 mg/kg (about 70 mg/m2) intravenously in a one year study.

Recommended dose rate in dogs is 1 - 2 mg/kg given intravenously weekly.

References

  1. Spiro T et al (2000) New cytotoxic agents for the treatment of metastatic malignant melanoma: temozolomide and related alkylating agents in combination with guanine analogues to abrogate drug resistance. Forum (Genova) 10(3):274-285
  2. Lucas C et al (1989) Interspecies comparison of pharmacokinetic parameters of fotemustine (nitrosourea S 10036): mice, rats, monkeys, dogs and man. Bull Cancer 76(8):863-865