Pathological changes are reported in the spinal cord, brain and pancreas.
Clinically affected dogs present with circling, ataxia, hypermetria and anorexia. As the disease progresses, symptoms invariably worsen, leading to euthanasia.
There is no known treatment for this condition.
- Knowles K et al (1993) Adult-onset lysosomal storage disease in a Schipperke dog: clinical, morphological and biochemical studies. Acta Neuropathol 86(3):306-312