From Dog

Galactosialidosis is a rare autosomal-recessive genetic lysosomal storage disease of the Schipperke.

This disease is caused by a defect in a protective protein Cathepsin A and leads to progressive neurological disease characterized by progressive cerebellar and central vestibular signs[1].

Pathological changes are reported in the spinal cord, brain and pancreas.

Clinically affected dogs present with circling, ataxia, hypermetria and anorexia. As the disease progresses, symptoms invariably worsen, leading to euthanasia.

There is no known treatment for this condition.


  1. Knowles K et al (1993) Adult-onset lysosomal storage disease in a Schipperke dog: clinical, morphological and biochemical studies. Acta Neuropathol 86(3):306-312