Glargine

From Dog

Glargine is a long-acting synthetic insulin used for the treatment of canine diabetes mellitus.

Glargine is a synthetic insulin analogue and is produced using recombinant DNA technology utilizing Escherichia coli.

Glargine has the advantage over protamine zinc insulin in rarely inducing hypoglycemia[1] and can be used as a single-dose once daily drug[2].

Recommended dose rate is 0.25 - 0.5 U/kg as a starting dose[3].

Glargine (Lantus) must not be diluted or mixed as this affects the peak effect[4].

References

  1. Fracassi F et al (2012) Use of insulin glargine in dogs with diabetes mellitus. Vet Rec 170(2):52
  2. Mori A et al (2008) Comparison of time-action profiles of insulin glargine and NPH insulin in normal and diabetic dogs. Vet Res Commun 32(7):563-573
  3. Gilor C & Graves TK (2010) Synthetic insulin analogs and their use in dogs and cats. Vet Clin North Am Small Anim Pract 40(2):297-307
  4. Hess, R & Ward. C (2000) Effect of insulin dosage on glycaemic response in dogs with diabetes mellitus: 221 cases (1993-1998). J Am Vet Med Assoc 216:217