Glycopyrrolate

From Dog

Glycopyrrolate is a muscarinic receptor antagonist which inhibits cholinergic transmission[1], similar in effect to atropine.

This drug, which does not mitigate the effects of medetomidine[2], has effects on sympathetic end-organs such as the respiratory and gastrointestinal tracts[3].

It is primarily used on dogs for bundle branch blocks, but can be used prior to general anesthesia to mitigate drooling or tracheal secretions[4].

Recommended dose rate in dogs is 0.005 - 0.010 mg/kg given intravenously or intramuscularly as needed.

References

  1. Casarosa P et al (2009) Preclinical evaluation of long-acting muscarinic antagonists: comparison of tiotropium and investigational drugs. J Pharmacol Exp Ther 330(2):660-668
  2. Enouri SS et al (2008) Effects of a peripheral alpha2 adrenergic-receptor antagonist on the hemodynamic changes induced by medetomidine administration in conscious dogs. Am J Vet Res 69(6):728-736
  3. Burger DM et al (2006) Effect of anticholinergics (atropine, glycopyrrolate) and prokinetics (metoclopramide, cisapride) on gastric motility in beagles and labrador retrievers. J Vet Med A Physiol Pathol Clin Med 53(2):97-107
  4. Lemmens S et al (2008) The cardiorespiratory effects of a fentanyl infusion following acepromazine and glycopyrrolate in dogs. Tijdschr Diergeneeskd 133(21):888-895