Heparin

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Heparin is an anticoagulant used as a preventative for thromboembolism and treatment of disseminated intravascular coagulation.

This drug is a synthetic drug originally prepared from porcine intestinal mucosa and bovine lung.

Heparin can be given intravenously or subcutaneously.

High-dose heparin therapy dose rate is 150 - 250 U/kg three times daily.

Lower doses are indicated in the management of DIC.

Blood coagulation times (eg, activated partial thromboplastin time) should be monitored during therapy.

Toxicities have been associated with this drug, particularly pericarditis.