Hormone responsive dermatoses are a group of rare skin diseases characterized by responsiveness to modulation of endogenous hormones.
A number of types have been recognized in dogs:
- Hyperestrogenism - ovarian imbalance type I in females
- - Seen in intact male dogs with testicular tumors (e.g. seminoma) and cryptorchidism - more common in the Boxer, Shetland Sheepdog, Weimaraner, German Shepherd, Cairn Terrier, Yorkshire Terrier, Pekingese and Collie
- - Male pseudohermaphrodite - affecting Miniature Schnauzer - associated with testicular tumors in intact, non-neutered males
- - Occurs after spaying in non-cycling, intact females, occasionally seen during false pregnancy
- - Variant - cyclical flank baldness and darkening of the skin in the Airedale, Boxer and English Bulldog
- Hypertestosteronism - androgen-producing testicular tumors - idiopathic male feminizing syndrome
- - Castration responsive in intact males - onset is at one to four years or older
- - Predisposition with the Chow Chow, Samoyed, Keeshonden, Pomeranian, Siberian Husky, Alaskan Malamute and Miniature Poodle
- Hypotestosteronism - testosterone-responsive – in older, castrated males - rare, predisposition with the Afghan Hound
- Growth hormone-responsive dermatosis - predisposition with Pomeranian, characterized by alopecia and hyperpigmentation of the trunk, caudal portion of the thighs, and ventral neck region.
- Hyperadrenocorticism - symmetrical alopecia
- Hypothyroidism - symmetrical alopecia
- Kim O & Kim KS (2005) Seminoma with hyperesterogenemia in a Yorkshire Terrier. J Vet Med Sci 67(1):121-123
- Schmeitzel LP & Lothrop CD (1990) Hormonal abnormalities in Pomeranians with normal coat and in Pomeranians with growth hormone-responsive dermatosis. J Am Vet Med Assoc 197(10):1333-1341