From Dog

Hypochloremia in dogs is defined as a serum chloride level <102 mmol/L.

The opposite condition is hyperchloremia.

In canine patients, this is commonly observed secondary to protracted vomiting and diarrhea, polyuria associated with diabetes mellitus[1], hypoadrenocorticism[2], vitamin D toxicosis[3] and salt-deficient home-made diets.

Concurrent azotemia, hypocalcemia, hyponatremia and hyperphosphatemia are common[4].

Depending on severity, clinical symptoms may include muscle weakness, dehydration and lethargy.

Correction of hypochloremia is readily achieved with intravenous saline solutions.


  1. Hess RS et al (2000) Concurrent disorders in dogs with diabetes mellitus: 221 cases (1993-1998). J Am Vet Med Assoc 217(8):1166-1173
  2. Saito M et al (2002) Muscle cramps in two standard poodles with hypoadrenocorticism. J Am Anim Hosp Assoc 38(5):437-443
  3. Nakamura Y et al (2004) Severe calcification of mucocutaneous and gastrointestinal tissues induced by high dose administration of vitamin D in a puppy. J Vet Med Sci 66(9):1133-1135
  4. Hutchinson D et al (2012) Seizures and severe nutrient deficiencies in a puppy fed a homemade diet. J Am Vet Med Assoc 241(4):477-483