Imidapril

From Dog

Imidapril is an angiotensin-converting enzyme inhibitor similar to benazepril.

This drug is primarily indicated for dogs with congestive heart failure, such as observed with mitral valve endocardiosis[1].

Although some side-effects have been reported, it is efficacious as other ACE inhibitors and appears to be well tolerated in dogs[2].

Imidapril also has cardioprotective effects against ischemia-reperfusion injury by decreasing infarct size, and through the antiarrhythmic effect and the reversal of increased overall contractility[3].

Recommended dose rate in dogs is 0.25 - 0.5 mg/kg given orally once daily[4].

References

  1. Lefebvre HP et al (2007) Angiotensin-converting enzyme inhibitors in veterinary medicine. Curr Pharm Des 13(13):134713-61
  2. Besche B et al (2012) Clinical evaluation of imidapril in congestive heart failure in dogs: results of the EFFIC study. J Small Anim Pract 48(5):265-170
  3. Hosoya K et al (2000) Force-length relationship in dogs as a measure of protective effect of imidapril on regional myocardial ischemia and reperfusion injury. Eur J Pharmacol 390(1-2):157-166
  4. Amberger C et al (2004) Comparison of the effects of imidapril and enalapril in a prospective, multicentric randomized trial in dogs with naturally acquired heart failure. J Vet Cardiol 6(2):9-16