Imidapril is an angiotensin-converting enzyme inhibitor similar to benazepril.
Although some side-effects have been reported, it is efficacious as other ACE inhibitors and appears to be well tolerated in dogs.
Imidapril also has cardioprotective effects against ischemia-reperfusion injury by decreasing infarct size, and through the antiarrhythmic effect and the reversal of increased overall contractility.
Recommended dose rate in dogs is 0.25 - 0.5 mg/kg given orally once daily.
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- Hosoya K et al (2000) Force-length relationship in dogs as a measure of protective effect of imidapril on regional myocardial ischemia and reperfusion injury. Eur J Pharmacol 390(1-2):157-166
- Amberger C et al (2004) Comparison of the effects of imidapril and enalapril in a prospective, multicentric randomized trial in dogs with naturally acquired heart failure. J Vet Cardiol 6(2):9-16