Itraconazole

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Itraconazole is a triazole antimycotic drug used in severe fungal infections in dogs[1] that are non-responsive to amphotericin B, terbinafine, or other azole drugs such as fluconazole or ketoconazole.

Itraconazole inhibits the fungal-mediated synthesis of ergosterol, resulting in fungal cell wall leakage of ions and resultant death.

This drug has also been used for treatment of systemic mycoses such as intestinal pythiosis[2].

Recommended dose rate is 10 mg/kg every 24 hours for 4 weeks (dermatophytes) or 4 - 6 months (systemic mycoses).

References

  1. López-Martínez R & Méndéz-Tovar LJ (2012) Blastomycosis. Clin Dermatol 30(6):565-572
  2. Schmiedt CW et al (2012) Treatment of intestinal pythiosis in a dog with a combination of marginal excision, chemotherapy, and immunotherapy. J Am Vet Med Assoc 241(3):358-363