Kanamycin

From Dog

Kanamycin is an aminoglycoside bacteriocidal antibiotic similar in action to neomycin, with activity against Gram-positive and Gram-negative bacteria.

Kanamycin shows good efficacy against Escherichia coli[1], but resistance to Staphylococcus pseudintermedius[2] and Enterococcus spp[3] have been reported.

High doses may induce ototoxic and nephrotoxic effects.

Recommended dose rate is 10 - 15 mg/kg given parenterally every 12 hours[4].

References

  1. Davis JA et al (2011) Anatomical distribution and genetic relatedness of antimicrobial-resistant Escherichia coli from healthy companion animals. J Appl Microbiol 110(2):597-604
  2. Perreten V et al (2010) Clonal spread of methicillin-resistant Staphylococcus pseudintermedius in Europe and North America: an international multicentre study. J Antimicrob Chemother. 65(6):1145-1154
  3. Jackson CR et al (2010) Mechanisms of antimicrobial resistance and genetic relatedness among enterococci isolated from dogs and cats in the United States. J Appl Microbiol 108(6):2171-2179
  4. KuKanich B & Coetzee JF (2008) Comparative pharmacokinetics of amikacin in Greyhound and Beagle dogs. J Vet Pharmacol Ther 31(2):102-107