Ketoconazole

From Dog
Ketoconazole01.jpg

Ketoconazole is a triazole antimycotic drug used in severe fungal infections in dogs[1] that are non-responsive to amphotericin B, terbinafine, or other azole drugs such as itraconazole or fluconazole.

Ketoconazole inhibits the fungal-mediated synthesis of ergosterol, resulting in fungal cell wall leakage of ions and resultant death.

This drug has also been used for treatment of systemic mycoses such as intestinal pythiosis[2] and in conjunction with flucytosine against Cladophialophora bantiana[3].

Recommended dose rate of ketoconazole is 5 - 15 mg/kg every 12 hours orally for 4 weeks (dermatophytes) or 4 - 6 months (systemic mycoses).

References

  1. López-Martínez R & Méndéz-Tovar LJ (2012) Blastomycosis. Clin Dermatol 30(6):565-572
  2. Schmiedt CW et al (2012) Treatment of intestinal pythiosis in a dog with a combination of marginal excision, chemotherapy, and immunotherapy. J Am Vet Med Assoc 241(3):358-363
  3. Guillot J et al (2004) Eumycetoma caused by Cladophialophora bantiana in a dog. J Clin Microbiol 42(10):4901-4903