Lasalocid is a carboxyl ionophore antibiotic that is used for the prevention of coccidiosis in chickens and turkeys, and as a growth promoter in ruminants. Dogs become poisoned from eating contaminated carcases or in dog food contaminated with this drug.
Clinical signs related to peripheral neurotoxicity within 12 hours post-consumption, leading to paralysis. Quadriparesis, salivation, hyperthermia and dyspnea are the major symptoms in the dogs, with some dogs showing tongue laxity, hyperaesthesia and anisochoria.
Serum biochemical abnormalities include high activities of creatine kinase, lactate dehydrogenase and aspartate aminotransferase.
A diagnosis is based on presenting clinical signs, hematological and biochemical evidence of hepatotoxicity and identification of the toxin in feed or carcases.
Treatment is usually supportive, with broad-spectrum antimicrobial therapy, intravenous fluids and placement of gastric tube feeding in severely dysphagic dogs.
- Segev G et al (2004) Accidental poisoning of 17 dogs with lasalocid. Vet Rec 155:174–176
- Espino L et al (2003) Suspected lasalocid poisoning in three dogs. Vet Hum Toxicol 45(5):241-242
- Safran Z et al (1993) Paralytic syndrome attributed to lasalocid residues in a commercial ration fed to dogs. J Am Vet Med Assoc 202:1273–1275
- Segev G et al (2004) Accidental poisoning of 17 dogs with lasalocid. Vet Rec 155(6):174-176
- Kaykaty M & Weiss G (1983) Lasalocid determination in animal blood by high-performance liquid chromatography fluorescence detection. J Agric Food Chem 31(1):81-84