Lithium salts such as lithium carbonate are commonly used in human medicine for a number of schizoaffective disorders and cyclic depression.
In dogs, it is rarely used for this condition but has a number of other applications as it has found to stimulate thrombopoiesis in clinically normal dogs.
Lithium has been used in canine medicine for treatment of thrombocytopenia associated with:
The method by which this drug stimulates bone marrow hyperplasia is unknown, but it has been shown to stimulate division of pluripotential stem cells.
Recommended dose rate in dogs is 10 - 20 mg/kg orally every 24 hours, in divided doses.
During lithium treatment of dogs, serum or plasma lithium concentrations should be measured weekly in order to see if the drug reaches optimum therapeutic levels of 0.5 - 1.8 mmol/L.
- Leclerc A et al (2010) Effects of lithium carbonate on carboplatin-induced thrombocytopenia in dogs. Am J Vet Res 71(5):555-563
- Hammond WP & Dale DC. Lithium therapy of canine cyclic hematopoiesis. Blood 55:26–28
- Maddux JM & Shaw SE (1983) Possible beneficial effect of lithium therapy in a case of estrogen-induced bone marrow hypoplasia in a dog: A case report. J Am Anim Hosp Assoc 19:242–245
- Shabidi NT & Diamond LK (1961) Testosterone-induced remission in aplastic anemia of both acquired and congenital types: Further observations in 24 cases. N Engl J Med 264:953–967